Hydrochloric Acid → HCID 131711061, compound

Participants

Reaction Steps

Nmr: δd 6-DMSO : 1.36d(8.0Hz)3H, 3.62s2H, 3.93q(8.0Hz)1H, 4.90d(5.0Hz)1H, 5.40s2H, 5.87dd(5.0;8.0Hz)1H, 7.2-8.4m1OH. (II) To a solution of p-nitrobenzyl 7-phenylacetamido-2-methyl-3-chloro-3cephem-4-carboxylate-1-oxide (38 mg) in dimethylformamide (2 ml) one adds stannous chloride dihydrate (44 mg) and acetyl chloride (0.2 ml), stirs for 3hours under ice cooling, adds 5% hydrochloric acid, extracts with ethyl acetate, washes with water, dries, and chromatographs on silica gel to give p-nitrobenzyl 7-phenylacetamido-2-methyl-3-chloro-3cephem-4-carboxylate (29 mg).

Provenance & Evidence