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HRID1679697

反应详情

EQUATION

反应方程式

HRID 1679697 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(=O)Cl
HCID6367

Acetyl chloride

C2H3ClO

结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：CC1C(Cl)=C(C(=O)OCc2ccc([N+](=O)[O-])cc2)N2C(=O)C(NC(=O)Cc3ccccc3)[C@H]2S1=O
HCID70616771

未命名化合物

PRODUCTS

生成物

1
结构：CC1S[C@@H]2C(NC(=O)Cc3ccccc3)C(=O)N2C(C(=O)OCc2ccc([N+](=O)[O-])cc2)=C1Cl
HCID131711061

未命名化合物

收率 78.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Nmr: δd 6-DMSO : 1.36d(8.0Hz)3H, 3.62s2H, 3.93q(8.0Hz)1H, 4.90d(5.0Hz)1H, 5.40s2H, 5.87dd(5.0;8.0Hz)1H, 7.2-8.4m1OH. (II) To a solution of p-nitrobenzyl 7-phenylacetamido-2-methyl-3-chloro-3cephem-4-carboxylate-1-oxide (38 mg) in dimethylformamide (2 ml) one adds stannous chloride dihydrate (44 mg) and acetyl chloride (0.2 ml), stirs for 3hours under ice cooling, adds 5% hydrochloric acid, extracts with ethyl acetate, washes with water, dries, and chromatographs on silica gel to give p-nitrobenzyl 7-phenylacetamido-2-methyl-3-chloro-3cephem-4-carboxylate (29 mg).