Methyl iodide → 2,2-Dimethyl-5-methoxy-6,7-dichloro-1-indanone

HRID 1679702Notes

Reaction equation

HRID 1679702 reaction equation
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11][CH3:12])[CH:8]=2)[C:3]1=[O:15].[H-].[Na+].[CH3:18]I>COCCOC>[CH3:1][C:2]1([CH3:18])[CH2:10][C:9]2[C:4](=[C:5]([Cl:14])[C:6]([Cl:13])=[C:7]([O:11][CH3:12])[CH:8]=2)[C:3]1=[O:15]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 123955612-Methyl-5-methoxy-6,7-dichloro-1-indanone

Product 1

HCID 123955652,2-Dimethyl-5-methoxy-6,7-dichloro-1-indanone

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
30 °C

Procedure

A stirred suspension of 2-methyl-5-methoxy-6,7-dichloro-1-indanone (12.2 g., 0.05 mole) and sodium hydride (1.43 g., 0.06 mole) in anhydrous 1,2-dimethoxyethane (500 ml.) is heated in an inert atmosphere at 80°-85° C. for 1 hour, cooled to 30° C. and treated with methyl iodide (8 ml.) The reaction mixture is refluxed for 15 minutes, then the solvent is distilled at reduced pressure. The crude product is poured into water (500 ml.), extracted into ether, washed with water and dried over magnesium sulfate. After evaporation of the ether the product is crystallized from methylcyclohexane affording 8.2 g. of 2,2-dimethyl-5-methoxy-6,7-dichloro-1-indanone which melts at 142° C.

Workup

  1. temperatureis heated in an inert atmosphere at 80°-85° C. for 1 hour
  2. temperatureis refluxed for 15 minutes
  3. distillationthe solvent is distilled at reduced pressure
  4. additionThe crude product is poured into water (500 ml.)
  5. extractionextracted into ether
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate
  8. customAfter evaporation of the ether the product
  9. customis crystallized from methylcyclohexane affording 8.2 g

Sources & evidence

ORD record
ord-cf8901f777bb40d18d62b239cf958f34
Source dataset
uspto-grants-1978_03
Patent number
US04081554

Reaction notes

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