Benzaldehyde → HCID 54411900, compound

HRID 1679747Notes

Reaction equation

HRID 1679747 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]1[C:15]([Cl:16])=[C:14]([O:17][CH3:18])[CH:13]=[CH:12][C:11]=1[C:19](=[O:23])[CH2:20][CH2:21][CH3:22].[OH-].[Na+]>C(O)C>[Cl:16][C:15]1[C:10]([Cl:9])=[C:11]([C:19](=[O:23])[C:20](=[CH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:21][CH3:22])[CH:12]=[CH:13][C:14]=1[O:17][CH3:18]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 14798Sodium HydroxideHCID 12395545HCID 12395545, compound

Product 1

HCID 54411900HCID 54411900, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of benzaldehyde (19.4 g., 0.183 mole) and 2',3'-dichloro-4'-methoxybutyrophenone (42.2 g., 0.183 mole) in absolute ethanol (350 ml.) a 20% sodium hydroxide solution (35.9 ml.) is added dropwise with stirring. The mixture is stirred for 22 hours. The white solid product that separates is collected and air dried. Yield 55.6 g. (91%), m.p. 127°-130° C.

Workup

  1. additionis added dropwise
  2. stirringThe mixture is stirred for 22 hours
  3. customThe white solid product that separates is collected
  4. customair dried

Sources & evidence

ORD record
ord-8108e4cc72fa4771b03c7d9b168c475b
Source dataset
uspto-grants-1978_03
Patent number
US04081554

Reaction notes

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