Trifluoroacetic acid → HCID 86735587, compound

HRID 1679785Notes

Reaction equation

HRID 1679785 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([CH3:20])[NH:8][C:9](=[O:19])[CH2:10][NH:11]C(OC(C)(C)C)=O.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[CH3:1][O:2][C:3](=[O:22])[CH2:4][NH:5][C:6](=[O:21])[C@H:7]([CH3:20])[NH:8][C:9](=[O:19])[CH2:10][NH2:11]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86735588HCID 86735588, compound

Product 1

HCID 86735587HCID 86735587, compound

Conditions

Temperature
0 °C

Procedure

Boc-Gly-Ala-Gly-OMe (6.4 g, 20.1 mmoles, described in Example 2) is dissolved in cold (ice bath) trifluoroacetic acid (120 ml) and the solution stirred at 0° C for 1 hr. The solvent is evaporated, the residue dissolved in methanol and the product precipitated with the addition of diethyl ether. The precipitiate is collected to give the title compound.

Workup

  1. customThe solvent is evaporated
  2. dissolutionthe residue dissolved in methanol
  3. customthe product precipitated with the addition of diethyl ether
  4. customThe precipitiate is collected

Sources & evidence

ORD record
ord-ecc9aa2f6fb04a0481ac1e5b0c1ae579
Source dataset
uspto-grants-1978_03
Patent number
US04081530

Reaction notes

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