Hydrazine hydrate (1:1) → HCID 86735589, compound

HRID 1679787Notes

Reaction equation

HRID 1679787 reaction equation
CO[C:3](=[O:26])[CH2:4][NH:5][C:6](=[O:25])[C@H:7]([CH3:24])[NH:8][C:9](=[O:23])[CH2:10][NH:11][C:12](=[O:22])[CH2:13][NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16].O.[NH2:28][NH2:29]>CO>[C:18]([O:17][C:15]([NH:14][CH2:13][C:12]([NH:11][CH2:10][C:9]([NH:8][C@H:7]([C:6]([NH:5][CH2:4][C:3]([NH:28][NH2:29])=[O:26])=[O:25])[CH3:24])=[O:23])=[O:22])=[O:16])([CH3:19])([CH3:20])[CH3:21]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86735590HCID 86735590, compound

Product 1

HCID 86735589HCID 86735589, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

To a cooled (ice bath), stirred solution of Boc-Gly-Gly-Ala-Gly-OMe (2.5 g, 6.7 mmoles, described in Example 4) in methanol (50 ml) is added hydrazine hydrate (2.5 ml). The solution is stirred at 0° C for 3 hr and at room temperature overnight. The precipitate is separated by filtration, washed with methanol and dried to yield the title compound; amino acid analysis: Gly 3, Ala 0.99.

Workup

  1. temperatureTo a cooled (ice bath)
  2. customThe precipitate is separated by filtration
  3. washwashed with methanol
  4. customdried

Sources & evidence

ORD record
ord-6bce0e4edfaf495284f2eef8a8284d0c
Source dataset
uspto-grants-1978_03
Patent number
US04081530

Reaction notes

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