HCID 86735590, compound → HCID 131711063, compound

HRID 1679788Notes

Reaction equation

HRID 1679788 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][NH:5][C:6](=[O:25])[C@H:7]([CH3:24])[NH:8][C:9](=[O:23])[CH2:10][NH:11][C:12](=[O:22])[CH2:13][NH:14]C(OC(C)(C)C)=O>FC(F)(F)C(O)=O>[NH2:14][CH2:13][C:12]([NH:11][CH2:10][C:9]([NH:8][C@H:7]([C:6]([NH:5][CH2:4][C:3]([O:2][CH3:1])=[O:26])=[O:25])[CH3:24])=[O:23])=[O:22]

Participants

3

Reactant 1

HCID 86735590HCID 86735590, compound

Product 1

HCID 131711063HCID 131711063, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Boc-Gly-Gly-Ala-Gly-OMe (2.0 g, 5.35 mmole, described in Example 4) in trifluoroacetic acid (25 ml) is stirred at 0° C for 1 hr. The solvent is evaporated, the residue triturated with ether, the solid collected and dried to give the tetrapeptide of formula H-Gly-Gly-Ala-Gly-OMe isolated as the trifluoroacetic acid addition salt.

Workup

  1. customThe solvent is evaporated
  2. customthe residue triturated with ether
  3. customthe solid collected
  4. customdried

Sources & evidence

ORD record
ord-02038cc34023458b96bf99db2fa0291c
Source dataset
uspto-grants-1978_03
Patent number
US04081530

Reaction notes

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