Hydrazine hydrate (1:1) → HCID 88813027, compound

HRID 1679790Notes

Reaction equation

HRID 1679790 reaction equation
[NH:1]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([NH:13][C@H:14]([C:16]([NH:18][CH2:19][C:20](OC)=[O:21])=[O:17])[CH3:15])=[O:12])=[O:8])=[O:4].O.[NH2:32][NH2:33]>CO>[C:27]([O:26][C:24]([NH:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([NH:13][C@H:14]([C:16]([NH:18][CH2:19][C:20]([NH:32][NH2:33])=[O:21])=[O:17])[CH3:15])=[O:12])=[O:8])=[O:4])=[O:25])([CH3:30])([CH3:29])[CH3:28]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 88813149HCID 88813149, compound

Product 1

HCID 88813027HCID 88813027, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Boc-Gly-Gly-Gly-Ala-Gly-OMe (1.0 g, 2.32 mmole, described in Example 16) and hydrazine hydrate (1 ml, 23.2 mmole) in methanol (30 ml) is stirred at 0° C for 4 hr. After evaporation the residue is triturated with diethyl ether and dried to give the title compound, mp 221° - 223° C.

Workup

  1. customAfter evaporation the residue
  2. customis triturated with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-88c7288a76b64689a4435e07571d9a4c
Source dataset
uspto-grants-1978_03
Patent number
US04081530

Reaction notes

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