HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Z-Asn-Leu-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | Z-Asn-onp | HCID 7021351 | — |
| Solvent | Water | HCID 962 | — |
| Product | Z-Asn-Leu-OMe | HCID 12814329 | — |
Reaction Steps
A solution of 16.7 g of H-Leu-OMe and 46.0 g of Z-Asn-ONP in 100 ml of freshly distilled dimethylformamide is kept for 19 hours at 25° C., then 1.2 litres of water are added and the crystalline precipitate is suctioned off. The dipeptide derivative is dried under vacuum at 40° C. and then twice recrystallized from aqueous methanol. It melts at 180°-181° C. Optical rotation [α]D20 =+9° (c=2.05 in chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04271068 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-63e663c4516545bbb8e1e9b52dd141bf |
| Source note | uspto-grants-1981_06 |