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HRID1679831

反应详情

EQUATION

反应方程式

HRID 1679831 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：COC(=O)[C@@H](N)CC(C)C
HCID65105

(S)-2-Amino-4-methylpentanoic acid methyl ester

C7H15NO2

结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1
HCID7021351

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1
HCID12814329

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 16.7 g of H-Leu-OMe and 46.0 g of Z-Asn-ONP in 100 ml of freshly distilled dimethylformamide is kept for 19 hours at 25° C., then 1.2 litres of water are added and the crystalline precipitate is suctioned off. The dipeptide derivative is dried under vacuum at 40° C. and then twice recrystallized from aqueous methanol. It melts at 180°-181° C. Optical rotation [α]D20 =+9° (c=2.05 in chloroform).

WORKUP

后处理

  1. dry with materialThe dipeptide derivative is dried under vacuum at 40° C.
  2. customtwice recrystallized from aqueous methanol
  3. customOptical rotation [α]D20 =+9° (c=2.05 in chloroform)