Z-Asn-Leu-OMe → H-Asn-Leu-OMe

HRID 1679832Notes

Reaction equation

HRID 1679832 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]>C(O)(C)(C)C.O.[C].[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]

Participants

4

Reactant 1

HCID 12814329Z-Asn-Leu-OMe

Product 1

HCID 57097841H-Asn-Leu-OMe

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 714019492-Methylpropan-2-ol--water (1/1)Solvent

Procedure

A solution of 15.0 g of Z-Asn-Leu-OMe in 400 ml of tertiary butanol+water (9:1) is hydrogenated in the presence of 2 g of palladium carbon (10% Pd). On completion of the hydrogenation the catalyst is suctioned off and the filtrate evaporated at 40° C. The residue is further used as it is.

Workup

  1. customthe filtrate evaporated at 40° C

Sources & evidence

ORD record
ord-a43bb85f02f44400976a0d9376999311
Source dataset
uspto-grants-1981_06
Patent number
US04271068

Reaction notes

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