反应详情

5.1 g sodium salt of N-hydroxyphthalimide and 1.9 g 2-chloromethyl imidazole hydrochloride (Journal of Chem. Soc. 1965,4577) are stirred at room temperature in dry methanol for 2 hours. The solvent is distilled off in vacuo and the residue treated with aqueous sodium bicarbonate and extracted 3 to 4 times with chloroform. The combined organic layers are dried over sodium sulfate, filtered and evaporated to dryness 1.7 g of 2-(1H-Imidazol-1-yl-methoxy)-1H-isoindole-1,3(2H)dione remains as crystalline solid with a melting point of 158°-160° C.

1. distillationThe solvent is distilled off in vacuo
2. additionthe residue treated with aqueous sodium bicarbonate
3. extractionextracted 3 to 4 times with chloroform
4. dry with materialThe combined organic layers are dried over sodium sulfate
5. filtrationfiltered
6. customevaporated to dryness 1.7 g of 2-(1H-Imidazol-1-yl-methoxy)-1H-isoindole-1,3(2H)dione