反应详情

A solution of 31.3 g of the crude 6-chloro-alpha,2-dibromotoluene in 100 ml of warm ethanol is treated with a solution of 6.7 g of potassium cyanide in 10 ml of water and the mixture is heated at reflux for 4 hours. The crude product is isolated by pouring the cooled reaction mixture into water and filtering the resulting precipitate. Recrystallization of this solid from aqueous ethanol then gives 12.4 g of 2-bromo-6-chlorophenylacetonitrile, mp 82°-84° C.

1. temperaturethe mixture is heated
2. temperatureat reflux for 4 hours
3. customThe crude product is isolated
4. additionby pouring
5. filtrationfiltering the resulting precipitate
6. customRecrystallization of this solid from aqueous ethanol