4-Amino-2-methylpyrimidine-5-carbaldehyde → HCID 12904730, compound

HRID 1679893Notes

Reaction equation

HRID 1679893 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][C:10]#[N:11].[NH2:12][C:13]1[C:18]([CH:19]=O)=[CH:17][N:16]=[C:15]([CH3:21])[N:14]=1>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:10]([NH2:11])=[N:12][C:13]2[N:14]=[C:15]([CH3:21])[N:16]=[CH:17][C:18]=2[CH:19]=1

Participants

3

Reactant 2

HCID 129047264-Amino-2-methylpyrimidine-5-carbaldehydeHCID 218500512-(2-broMo-6-chlorophenyl)acetonitrile

Product 1

HCID 12904730HCID 12904730, compound

Procedure

Following the procedure for Example 1, 2-bromo-6-chlorophenylacetonitrile is condensed with 4-amino-2-methylpyrimidin-5-carboxaldehyde to give 6-(2-bromo-6-chlorophenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine, mp 272°-274° C., after recrystallization from acetonitrile.

Sources & evidence

ORD record
ord-dfa74eacda304a88a837dd211a33d75c
Source dataset
uspto-grants-1981_06
Patent number
US04271164

Reaction notes

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