4-Amino-2-methylpyrimidine-5-carbaldehyde → 6-(2-Chloro-6-methylphenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine

HRID 1679897Notes

Reaction equation

HRID 1679897 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[CH2:9][C:10]#[N:11].[NH2:12][C:13]1[C:18]([CH:19]=O)=[CH:17][N:16]=[C:15]([CH3:21])[N:14]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[C:10]([NH2:11])=[N:12][C:13]2[N:14]=[C:15]([CH3:21])[N:16]=[CH:17][C:18]=2[CH:19]=1

Participants

3

Reactant 2

HCID 129047264-Amino-2-methylpyrimidine-5-carbaldehydeHCID 542461202-(2-Chloro-6-methylphenyl)acetonitrile

Product 1

HCID 129047316-(2-Chloro-6-methylphenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine

Procedure

Following the procedure of Example 1, 2-chloro-6-methylphenylacetonitrile is condensed with 4-amino-2-methylpyrimidine-5-carboxaldehyde to give 6-(2-chloro-6-methylphenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine, mp 267°-271° C., after recrystallization from isopropanol.

Sources & evidence

ORD record
ord-6f2f6eeefbb84343822b2f2e603f0a32
Source dataset
uspto-grants-1981_06
Patent number
US04271164

Reaction notes

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