HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2-methylpyrimidine-5-carbaldehyde → 6-(2-Chloro-6-methylphenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2-methylpyrimidine-5-carbaldehyde | HCID 12904726 | — |
| Reactant | 2-(2-Chloro-6-methylphenyl)acetonitrile | HCID 54246120 | — |
| Product | 6-(2-Chloro-6-methylphenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine | HCID 12904731 | — |
Reaction Steps
Following the procedure of Example 1, 2-chloro-6-methylphenylacetonitrile is condensed with 4-amino-2-methylpyrimidine-5-carboxaldehyde to give 6-(2-chloro-6-methylphenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine, mp 267°-271° C., after recrystallization from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04271164 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-6f2f6eeefbb84343822b2f2e603f0a32 |
| Source note | uspto-grants-1981_06 |