Water → HCID 23458559, compound

Participants

Reaction Steps

10.0 g (49.7 millimoles) of 2-(p-aminophenyl)-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one (see Example 8a), 6.6 g (49.9 millimoles) of 2,5-dimethoxytetrahydrofuran and 100 ml of acetic acid are refluxed for 4 hours. The product is filtered off at 10° C. and recrystallized from a dimethylformamide/water mixture. 5.2 g (41% of theory) of 2-[p-(pyrrol-1-yl)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-2-en-5-one, hydrated with one mole of water per four moles of compound, are obtained as beige crystals, of melting point 230°-231° C.

Provenance & Evidence