Hydrochloric Acid → HCID 23458682, compound

Participants

Reaction Steps

The procedure of Example 8 is followed, but a suspension of phenacyl 5-chloropyrid-2-yldithiocarbamate (23.1 g) in acetonitrile (240 cc) and a solution of potassium borohydride (3.9 g) in distilled water (60 cc) are used as the starting materials at between 20° and 28° C. The reaction is allowed to proceed for 45 minutes at 25° C. After adding a 3 N aqueous solution of hydrochloric acid (23.8 cc), filtering off the crystals, washing them with ice-cooled acetonitrile (15 cc) and then three times with distilled water (180 cc in total) and drying them under reduced pressure (0.2 mm Hg) at 40° C., 2-hydroxy-2-phenylethyl 5-chloropyrid-2-yldithiocarbamate (13.6 g), which melts at 116° C., is obtained.

Provenance & Evidence