HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dicyclohexylcarbodiimide → Z-Thr-Pro-OtBu
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | N-((Benzyloxy)carbonyl)-L-threonine | HCID 88217 | — |
| Edukt | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | Z-Thr-Pro-OtBu | HCID 131712253 | 64% |
Reaktionsschritte
In the way described in B(1), 0.33 mol Z-Thr-OH and 0.35 mol H-Pro-OtBu are coupled with the aid of HOBt and DCCI in DMF. Yield 64%; melting point 65°-67° C. The Z-Thr-Pro-OtBu obtained in this way is hydrogenated in the way described above (see B.3.b.).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04271152 |
| Quelldatensatz | uspto-grants-1981_06 |
| ORD ID | ord-8a64b2cbc55043c8adcb6e87a248f493 |
| Quellennotiz | uspto-grants-1981_06 |