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HRID1680051

反应详情

EQUATION

反应方程式

HRID 1680051 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：C[C@@H](O)[C@H](NC(=O)OCc1ccccc1)C(=O)O
HCID88217

N-((Benzyloxy)carbonyl)-L-threonine

C12H15NO5

结构：CC(C)(C)OC(=O)[C@@H]1CCCN1
HCID6453108

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](O)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C
HCID131712253

未命名化合物

收率 64%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In the way described in B(1), 0.33 mol Z-Thr-OH and 0.35 mol H-Pro-OtBu are coupled with the aid of HOBt and DCCI in DMF. Yield 64%; melting point 65°-67° C. The Z-Thr-Pro-OtBu obtained in this way is hydrogenated in the way described above (see B.3.b.).