2212-69-3 → Z-Lys(Boc)-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

HRID 1680054Notes

Reaction equation

HRID 1680054 reaction equation
[CH3:1][C:2]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:26][C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28])[C:14]([O:16]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:7])([CH3:4])[CH3:3].[NH2:37][C@H:38]([C:41]([NH:43][C@H:44]([C:50]([NH:52][C@H:53]([C:57]([N:59]1[CH2:100][CH2:99][CH2:98][C@H:60]1[C:61]([NH:63][C@H:64]([C:69]([NH:71][C@H:72]([C:76]([NH:78][C@H:79]([C:83]([NH:85][C@H:86]([C:91]([O:93][C:94]([CH3:97])([CH3:96])[CH3:95])=[O:92])[CH2:87][CH:88]([CH3:90])[CH3:89])=[O:84])[C@@H:80]([CH3:82])[OH:81])=[O:77])[CH:73]([CH3:75])[CH3:74])=[O:70])[CH2:65][CH:66]([CH3:68])[CH3:67])=[O:62])=[O:58])[C@@H:54]([CH3:56])[OH:55])=[O:51])[CH2:45][CH2:46][C:47](=[O:49])[NH2:48])=[O:42])[CH2:39][OH:40]>CN(C=O)C>[NH:26]([C:27]([O:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:28])[C@H:13]([C:14]([NH:37][C@H:38]([C:41]([NH:43][C@H:44]([C:50]([NH:52][C@H:53]([C:57]([N:59]1[CH2:100][CH2:99][CH2:98][C@H:60]1[C:61]([NH:63][C@H:64]([C:69]([NH:71][C@H:72]([C:76]([NH:78][C@H:79]([C:83]([NH:85][C@H:86]([C:91]([O:93][C:94]([CH3:96])([CH3:95])[CH3:97])=[O:92])[CH2:87][CH:88]([CH3:89])[CH3:90])=[O:84])[C@@H:80]([CH3:82])[OH:81])=[O:77])[CH:73]([CH3:74])[CH3:75])=[O:70])[CH2:65][CH:66]([CH3:67])[CH3:68])=[O:62])=[O:58])[C@@H:54]([CH3:56])[OH:55])=[O:51])[CH2:45][CH2:46][C:47](=[O:49])[NH2:48])=[O:42])[CH2:39][OH:40])=[O:16])[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])=[O:7]

Participants

4

Reactant 2

HCID 135032652212-69-3HCID 131712256H-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

Product 1

HCID 131712255Z-Lys(Boc)-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.35 g Z-Lys(Boc)-ONp (2.7 mmol) and 2.42 g (2.64 mmol) H-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OtBu (F. 1) are dissolved in 35 ml DMF. After stirring at room temperature for 18 hours the reaction mixture is evaporated to dryness.

Workup

  1. customis evaporated to dryness

Sources & evidence

ORD record
ord-09eca54661dc45849e6068ba366ff1f2
Source dataset
uspto-grants-1981_06
Patent number
US04271152

Reaction notes

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