Hydrogen Peroxide → HCID 131712259, compound

HRID 1680056Notes

Reaction equation

HRID 1680056 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([NH:16][C@H:17]([C:22]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([C:35]([NH:37][C@H:38]([C:44]([NH:46][C@H:47]([C:53]([NH:55][C@H:56]([C:59]([NH:61][C@H:62]([C:68]([NH:70][C@H:71]([C:75]([N:77]1[CH2:114][CH2:113][CH2:112][C@H:78]1[C:79]([NH:81][C@H:82]([C:87]([NH:89][C@H:90]([C:94]([NH:96][C@H:97]([C:101]([NH:103][C@H:104]([C:109]([OH:111])=[O:110])[CH2:105][CH:106]([CH3:108])[CH3:107])=[O:102])[C@@H:98]([CH3:100])[OH:99])=[O:95])[CH:91]([CH3:93])[CH3:92])=[O:88])[CH2:83][CH:84]([CH3:86])[CH3:85])=[O:80])=[O:76])[C@@H:72]([CH3:74])[OH:73])=[O:69])[CH2:63][CH2:64][C:65](=[O:67])[NH2:66])=[O:60])[CH2:57][OH:58])=[O:54])[CH2:48][CH2:49][CH2:50][CH2:51][NH2:52])=[O:45])[CH2:39][CH2:40][C:41](=[O:43])[OH:42])=[O:36])[CH2:33][OH:34])=[O:30])[C@@H:26]([CH3:28])[OH:27])=[O:23])[CH2:18][CH2:19][S:20][CH3:21])=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[OH2:115].[OH:116]O.C(O)(C)(C)C.O>C([O-])(=O)C.[NH4+].[NH4+].[O-][Mo]([O-])(=O)=O>[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([NH:16][C@H:17]([C:22]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([C:35]([NH:37][C@H:38]([C:44]([NH:46][C@H:47]([C:53]([NH:55][C@H:56]([C:59]([NH:61][C@H:62]([C:68]([NH:70][C@H:71]([C:75]([N:77]1[CH2:114][CH2:113][CH2:112][C@H:78]1[C:79]([NH:81][C@H:82]([C:87]([NH:89][C@H:90]([C:94]([NH:96][C@H:97]([C:101]([NH:103][C@H:104]([C:109]([OH:111])=[O:110])[CH2:105][CH:106]([CH3:108])[CH3:107])=[O:102])[C@@H:98]([CH3:100])[OH:99])=[O:95])[CH:91]([CH3:93])[CH3:92])=[O:88])[CH2:83][CH:84]([CH3:86])[CH3:85])=[O:80])=[O:76])[C@@H:72]([CH3:74])[OH:73])=[O:69])[CH2:63][CH2:64][C:65](=[O:67])[NH2:66])=[O:60])[CH2:57][OH:58])=[O:54])[CH2:48][CH2:49][CH2:50][CH2:51][NH2:52])=[O:45])[CH2:39][CH2:40][C:41](=[O:42])[OH:43])=[O:36])[CH2:33][OH:34])=[O:30])[C@@H:26]([CH3:28])[OH:27])=[O:23])[CH2:18][CH2:19][S:20]([CH3:21])(=[O:116])=[O:115])=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]

Participants

7

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 714019492-Methylpropan-2-ol--water (1/1)HCID 131712260HCID 131712260, compound

Product 1

HCID 131712259HCID 131712259, compound

Reagents, catalysts & solvents 2

HCID 61578Diammonium molybdateCatalystHCID 175AcetateSolvent

Procedure

200 mg Of the peptide obtained in Example I are introduced into 5 ml of water to which are added in order of succession 0.025 ml of 0.5 M ammonium molybdate, 0.125 ml HClO4, and 0.075 ml of 30% hydrogen peroxide. The mixture is stirred at room temperature for 4 hours, after which 5 ml of tertiary butanol/water (1:1) and ion exchanger in acetate form are added. After stirring for half an hour the ion exchanger is filtered out and the filtrate is evaporated to dryness. Yield 175 mg of peptide (in the form of an acetate).

Workup

  1. stirringAfter stirring for half an hour the ion exchanger
  2. filtrationis filtered out
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-ac1e38bad42e42bf87f777de996e4ea4
Source dataset
uspto-grants-1981_06
Patent number
US04271152

Reaction notes

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