Morpholine → HCID 23459045, compound

HRID 1680067Notes

Reaction equation

HRID 1680067 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]([O:20][CH2:21][CH2:22]Cl)([C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>CCOCC>[O:27]1[CH2:28][CH2:29][N:24]([CH2:2][CH2:3][O:4][C:5]([O:20][CH2:21][CH2:22][N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:13])[CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 14762563HCID 14762563, compound

Product 1

HCID 23459045HCID 23459045, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

With stirring, 35 g (0.1 mole) of benzil-di-(2-chloroethyl)ketal and 52 g (0.6 mole) of morpholine are kept for 6 hours at 110° C. After cooling, the product is taken up in ether. The ether layer is washed with water, dried over Na2SO4 and concentrated. The residual oil is dried in a high vacuum at 50°-60° C.

Workup

  1. temperatureAfter cooling
  2. washThe ether layer is washed with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe residual oil is dried in a high vacuum at 50°-60° C.

Sources & evidence

ORD record
ord-d51f6c29f9e0474199093b04b4563e3e
Source dataset
uspto-grants-1981_06
Patent number
US04271294

Reaction notes

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