Hydrochloric Acid → HCID 12906310, compound

HRID 1680111Notes

Reaction equation

HRID 1680111 reaction equation
C(O[C:6]([N:8]([N:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1)C)=O)(C)(C)C.[ClH:19]>>[ClH:19].[CH3:6][NH:8][N:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12906308HCID 12906308, compound

Product 1

HCID 12906310HCID 12906310, compound

Procedure

To the crude N-(t-butyloxycarbonyl-N-methylamino)dihydroisoindole from the above preparation was added 25 ml of concentrated hydrochloric acid. The reaction mixture was allowed to stir for one hour. Evaporation of the mixture to dryness and recrystallization of the residue from ethanol-ether gave 5.6 g of the desired product as a gummy solid, mp: 79°-89°. The IR and NMR were consistent with the proposed structure.

Workup

  1. customEvaporation of the mixture
  2. customto dryness and recrystallization of the residue from ethanol-ether

Sources & evidence

ORD record
ord-8e4f2fc0c5574210b7bd03e5c766fa7f
Source dataset
uspto-grants-1981_06
Patent number
US04272284

Reaction notes

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