Hydrazine hydrate (1:1) → HCID 23457066, compound

HRID 1680126Notes

Reaction equation

HRID 1680126 reaction equation
ClC1C=CC=CC=1OC.Cl[C:11]1[C:16]([C:17]2[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[N:15][NH:14][C:13](=[O:26])[CH:12]=1.[NH:27]1C(=O)C=CC=[N:28]1.O.NN>>[NH:27]([C:11]1[C:16]([C:17]2[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[N:15][NH:14][C:13](=[O:26])[CH:12]=1)[NH2:28]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86737771HCID 86737771, compound

Product 1

HCID 23457066HCID 23457066, compoundYield 90%

Procedure

A mixture of 1.5 g (0.005 mol) of 5-chloro-6-(2'-methoxy-5'-chlorophenyl)-3-pyridazinone chloroanisole-6-pyridazinone and 25 ml of hydrazine hydrate was heated at reflux for 4 hours. The solution was cooled and the white solid which formed was separated, washed with water (30 ml) and dried at 40° in a vacuum oven overnight to give 1.2 g (81%) of a colorless solid product, m.p. 285°-290°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. temperatureThe solution was cooled
  4. customthe white solid which formed
  5. customwas separated
  6. washwashed with water (30 ml)
  7. customdried at 40° in a vacuum oven overnight

Sources & evidence

ORD record
ord-c8126d6ea99f4ec0bc2b6ae16863f32f
Source dataset
uspto-grants-1981_06
Patent number
US04272440

Reaction notes

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