Hydrochloric Acid → HCID 23457310, compound

HRID 1680176Notes

Reaction equation

HRID 1680176 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[C:6]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])=[C:5]2[CH3:23].Cl>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[CH:6]([CH2:18][CH2:19][N:20]([CH3:21])[CH3:22])[CH:5]2[CH3:23]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 23457309HCID 23457309, compound

Product 1

HCID 23457310HCID 23457310, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compounds are produced in analogous manner to Example 2, using 5-chloro-1-p-chlorophenyl-2-(2-dimethylaminoethyl)-3-methylindole as starting compound. The major product is the cis compound. M.Pt. of the hydrochloride: 187°-190°. The trans compound is isolated from the mother liquor. M.Pt. of the hydrochloride: 163°-168° (both from acetone).

Workup

  1. custom187°-190°
  2. customThe trans compound is isolated from the mother liquor
  3. custom163°-168°

Sources & evidence

ORD record
ord-f12a2f3cd462425bb9d21aa30489c924
Source dataset
uspto-grants-1981_06
Patent number
US04272533

Reaction notes

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