Potassium Iodide → HCID 70552786, compound

HRID 1680180Notes

Reaction equation

HRID 1680180 reaction equation
[C:1]12([NH:12][C:13](=[O:16])[CH2:14][Cl:15])[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1.[CH:17]1([NH2:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C(=O)([O-])O.[Na+].[I-].[K+]>C(O)C>[ClH:15].[C:1]12([NH:12][C:13](=[O:16])[CH2:14][NH:23][CH:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 7965CyclohexylamineHCID 516892Sodium BicarbonateHCID 53852481HCID 53852481, compound

Product 1

HCID 70552786HCID 70552786, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1.20 g (4.96 millimoles) of N-(1-tricyclo[4.3.1.12,5 ]undecyl)-2-chloroacetamide and 0.49 g (4.96 millimoles) of cyclohexylamine in ethanol was mixed with 5 ml of an aqueous solution containing 0.42 g (4.96 millimoles) of sodium hydrogencarbonate and 8.2 mg (0.49 millimole) of potassium iodide, and the mixture was refluxed, under agitation, for 15 hours. The post treatment was carried out in the same manner as described in section (B) of Example 1 to obtain 1.01 g (the yield being 59.8%) of white crystals of the intended compound having a melting point of 192°-195° C. (recrystallized from methanol-acetone).

Workup

  1. temperaturethe mixture was refluxed, under agitation, for 15 hours
  2. customto obtain 1.01 g (the yield
  3. customa melting point of 192°-195° C. (recrystallized from methanol-acetone)

Sources & evidence

ORD record
ord-1feb3e54a2cd4969b22acb1d006b3de6
Source dataset
uspto-grants-1981_06
Patent number
US04272536

Reaction notes

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