Methyl Isocyanate → HCID 12876307, compound

HRID 1680203Notes

Reaction equation

HRID 1680203 reaction equation
[CH3:1][C:2]1([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH2:5][CH2:4][NH:3]1)=[CH:13][CH:12]=[CH:11][CH:10]=3.[CH3:21][N:22]=[C:23]=[O:24]>C1CCCCC1>[CH3:1][C:2]1([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH2:5][CH2:4][N:3]1[C:23]([NH:22][CH3:21])=[O:24])=[CH:13][CH:12]=[CH:11][CH:10]=3

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 192046HCID 192046, compound

Product 1

HCID 12876307HCID 12876307, compound

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

10.9 g (0.04 mol) of ethyl 1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-acetate are suspended in 200 ml of cyclohexane. 3 ml (0.04 mol) of methyl isocyanate are added. The mixture is heated under reflux for 1 hour. It is allowed to cool overnight in a refrigerator. The precipitate is filtered off. The product is recrystallised from ethanol.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 1 hour
  3. temperatureto cool overnight in a refrigerator
  4. filtrationThe precipitate is filtered off
  5. customThe product is recrystallised from ethanol

Sources & evidence

ORD record
ord-b25d27eba5da4af7927b7ce0206b20c2
Source dataset
uspto-grants-1981_06
Patent number
US04272539

Reaction notes

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