Ethanolamine → N-Trifluoroacetyl-2-aminoethanol

HRID 1680206Notes

Reaction equation

HRID 1680206 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].CCS[C:8]([C:10]([F:13])([F:12])[F:11])=[O:9]>CO>[F:11][C:10]([F:13])([F:12])[C:8]([NH:4][CH2:3][CH2:1][OH:2])=[O:9]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 67844Ethylthiol trifluoroacetate

Product 1

HCID 95211N-Trifluoroacetyl-2-aminoethanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethanolamine (12 g) is dissolved in methanol (50 ml) and S-ethylthiotrifluoroacetate (35 g) is added dropwise. The reaction is permitted to stand overnight irrigated with a stream of argon to remove ethanethiol. The excess solvent is removed in vacuo to leave the title product.

Workup

  1. customto remove ethanethiol
  2. customThe excess solvent is removed in vacuo

Sources & evidence

ORD record
ord-081d54460a784969b6ff6bd41a780154
Source dataset
uspto-grants-1981_06
Patent number
US04272525

Reaction notes

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