Dicyclohexylcarbodiimide → HCID 86737791, compound

HRID 1680207Notes

Reaction equation

HRID 1680207 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].O[N:13]1[C:17](=[O:18])[CH2:16][CH2:15][C:14]1=[O:19].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[F:1][C:2]([F:10])([F:11])[C:3]([NH:5][CH2:6][C:7]([O:9][CH:15]1[CH2:16][C:17](=[O:18])[NH:13][C:14]1=[O:19])=[O:8])=[O:4]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 80170N-HydroxysuccinimideHCID 136227N-(trifluoroacetyl)aminoacetic acid

Product 1

HCID 86737791HCID 86737791, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

N-Trifluoroacetylglycine (684 mg) and N-hydroxysuccinimide (480 mg) in 5 ml of dry CH2Cl2 at 50° C. are treated with a solution of 915 mg dicyclohexylcarbodiimide (4.43 mmol) in 5 ml of CH2Cl2. The mixture is stirred at room temperature overnight, is then filtered and evaporated to produce the named compound which can be used in subsequent reactions without further purification.

Workup

  1. filtrationis then filtered
  2. customevaporated
  3. customto produce the named compound which
  4. customcan be used in subsequent reactions without further purification

Sources & evidence

ORD record
ord-64750fedbb2743c6ae1227b0ee8ea70e
Source dataset
uspto-grants-1981_06
Patent number
US04272525

Reaction notes

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