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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1680207Generated: October 31, 2026

Dicyclohexylcarbodiimide → HCID 86737791, compound

https://huagongshe.com/reaction/1680207

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantN-HydroxysuccinimideHCID 80170—
ReactantN-(trifluoroacetyl)aminoacetic acidHCID 136227—
SolventDichloromethaneHCID 6344—
ProductHCID 86737791HCID 86737791—

Reaction Steps

N-Trifluoroacetylglycine (684 mg) and N-hydroxysuccinimide (480 mg) in 5 ml of dry CH2Cl2 at 50° C. are treated with a solution of 915 mg dicyclohexylcarbodiimide (4.43 mmol) in 5 ml of CH2Cl2. The mixture is stirred at room temperature overnight, is then filtered and evaporated to produce the named compound which can be used in subsequent reactions without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04272525
Source datasetuspto-grants-1981_06
ORD IDord-64750fedbb2743c6ae1227b0ee8ea70e
Source noteuspto-grants-1981_06