Thionyl Chloride → HCID 23457691, compound

HRID 1680213Notes

Reaction equation

HRID 1680213 reaction equation
O[CH:2]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.S(Cl)([Cl:21])=O>>[ClH:21].[Cl:21][CH:2]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 13457358HCID 13457358, compound

Product 1

HCID 23457691HCID 23457691, compound

Procedure

1-[2-Hydroxy-4-(4-methoxyphenyl)-n-butyl]imidazole (2.0 g) is treated with thionyl chloride (10 ml) and the solution stirred for one hour at 60°. The solvent is evaporated under reduced pressure and the residue crystallized from ethyl acetate/ether, filtered, washed with ethyl acetate and dried in air to give 1-[2-chloro-4-(4-methoxyphenyl)-n-butyl]imidazole hydrochloride.

Workup

  1. customThe solvent is evaporated under reduced pressure
  2. customthe residue crystallized from ethyl acetate/ether
  3. filtrationfiltered
  4. washwashed with ethyl acetate
  5. customdried in air

Sources & evidence

ORD record
ord-2a1635b2142e40919688b04cba17fa26
Source dataset
uspto-grants-1981_06
Patent number
US04272545

Reaction notes

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