Thionyl Chloride → HCID 23457691, compound

Participants

Reaction Steps

1-[2-Hydroxy-4-(4-methoxyphenyl)-n-butyl]imidazole (2.0 g) is treated with thionyl chloride (10 ml) and the solution stirred for one hour at 60°. The solvent is evaporated under reduced pressure and the residue crystallized from ethyl acetate/ether, filtered, washed with ethyl acetate and dried in air to give 1-[2-chloro-4-(4-methoxyphenyl)-n-butyl]imidazole hydrochloride.

Provenance & Evidence