Hydrochloric Acid → HCID 70567751, compound

Participants

Reaction Steps

3,14-Dimethoxymorphinan-6-one hydrochloride (6b) was prepared by refluxing 17-cyano-3,14-dimethoxymorphinan-6-one (5) (0.385 g, 1.18 mmol) in 25 ml of 2 N hydrochloric acid for 4 hours. The solution was concentrated under reduced pressure to give 0.360 g (91% theory) of (6b) as a white solid which was used without further purification in the preparation of the N-cyclobutyl derivative.

Provenance & Evidence