Hydrochloric Acid → HCID 70567751, compound

HRID 1680219Notes

Reaction equation

HRID 1680219 reaction equation
C([N:3]1[CH2:21][CH2:20][C@@:10]23[C:11]4[CH:12]=[C:13]([O:18][CH3:19])[CH:14]=[CH:15][C:16]=4[CH2:17][C@@H:4]1[C@:5]2([O:23][CH3:24])[CH2:6][CH2:7][C:8](=[O:22])[CH2:9]3)#N.[ClH:25]>>[ClH:25].[CH3:19][O:18][C:13]1[CH:14]=[CH:15][C:16]2[CH2:17][C@H:4]3[NH:3][CH2:21][CH2:20][C@@:10]4([C:11]=2[CH:12]=1)[C@@:5]3([O:23][CH3:24])[CH2:6][CH2:7][C:8](=[O:22])[CH2:9]4

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57271803HCID 57271803, compound

Product 1

HCID 70567751HCID 70567751, compound

Procedure

3,14-Dimethoxymorphinan-6-one hydrochloride (6b) was prepared by refluxing 17-cyano-3,14-dimethoxymorphinan-6-one (5) (0.385 g, 1.18 mmol) in 25 ml of 2 N hydrochloric acid for 4 hours. The solution was concentrated under reduced pressure to give 0.360 g (91% theory) of (6b) as a white solid which was used without further purification in the preparation of the N-cyclobutyl derivative.

Workup

  1. custom3,14-Dimethoxymorphinan-6-one hydrochloride (6b) was prepared
  2. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-778ca7d9f60b40c6b25a5a145ff1f5b9
Source dataset
uspto-grants-1981_06
Patent number
US04272540

Reaction notes

Loading…