Hydrochloric Acid → HCID 70572091, compound

HRID 1680241Notes

Reaction equation

HRID 1680241 reaction equation
C([N:3]1[CH2:22][CH2:21][C@:10]23[C:11]4[C:12]5[O:20][C@H:9]2[C:8](=[O:23])[CH2:7][C@H:6]([CH2:24][CH3:25])[C@H:5]3[C@H:4]1[CH2:17][C:16]=4[CH:15]=[CH:14][C:13]=5[O:18][CH3:19])#N.[ClH:26]>>[ClH:26].[O:20]1[C@@H:9]2[C@@:10]34[CH2:21][CH2:22][NH:3][C@@H:4]([C@@H:5]3[C@@H:6]([CH2:24][CH3:25])[CH2:7][C:8]2=[O:23])[CH2:17][C:16]2=[C:11]4[C:12]1=[C:13]([O:18][CH3:19])[CH:14]=[CH:15]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86737777HCID 86737777, compound

Product 1

HCID 70572091HCID 70572091, compoundYield 89%

Procedure

A suspension of 17-cyano-4,5α-epoxy-8β-ethyl-3-methoxymorphinan-6-one (4.30 g; prepared in Part B) in 100 ml 2 N HCl was refluxed for 4 hours. The solution was evaporated to a crystalline residue which was suspended in ethanol. After cooling, the crystals were collected and dried to give 3.95 g (89%) of product, mp. decomposes slowly above 260° C.

Workup

  1. temperaturewas refluxed for 4 hours
  2. customThe solution was evaporated to a crystalline residue which
  3. temperatureAfter cooling
  4. customthe crystals were collected
  5. customdried

Sources & evidence

ORD record
ord-1ca32f134e2f43fe94e8e7b95da5fc57
Source dataset
uspto-grants-1981_06
Patent number
US04272541

Reaction notes

Loading…