Hydrochloric Acid → HCID 12898551, compound

HRID 1680254Notes

Reaction equation

HRID 1680254 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]([C:9]1[CH:21]=[C:20]([CH3:22])[C:12]([O:13][CH2:14][C:15]([O:17]CC)=[O:16])=[C:11]([CH3:23])[CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].[OH-].[Na+].Cl>>[F:1][C:2]([F:24])([F:25])[C:3]([C:9]1[CH:21]=[C:20]([CH3:22])[C:12]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:11]([CH3:23])[CH:10]=1)([OH:8])[C:4]([F:5])([F:7])[F:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12898550HCID 12898550, compound

Product 1

HCID 12898551HCID 12898551, compound

Procedure

Stir together for 16 hours a mixture of ethyl 2-[4-(hexafluoro-2-hydroxy-2-propyl)-2,6-dimethylphenoxy]acetate (7.1 g=19 mmol) and 125 ml 1.0 N NaOH. Acidify with concentrated HCl and extract with ether. Dry and concentrate the ether. Recrystallize from ether-hexane to obtain, as white crystals, 2-[4-(hexafluoro-2-hydroxy-2-propyl)-2,6-dimethylphenoxy]acetic acid, m.p. 118°-120° C.

Workup

  1. extractionextract with ether
  2. customDry
  3. concentrationconcentrate the ether
  4. customRecrystallize from ether-hexane

Sources & evidence

ORD record
ord-a8ef2f71b2b24405b00ace1d6677ff55
Source dataset
uspto-grants-1981_06
Patent number
US04272550

Reaction notes

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