3-Fluorobenzaldehyde → HCID 53820628, compound

HRID 1680445Notes

Reaction equation

HRID 1680445 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][N:6]=1)=[O:4].[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]=[CH:16][C:15]2[CH:18]=[CH:19][CH:20]=[C:13]([F:12])[CH:14]=2)=[CH:7][N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 12457877Methyl 5-aminopyridine-2-carboxylate

Product 1

HCID 53820628HCID 53820628, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The starting material is prepared as follows: The mixture of 11.25 g of 5-aminopyridine-2-carboxylic acid methyl ester, 10.0 g of m-fluorobenzaldehyde and 50 ml of benzene is refluxed for 22 hours on a water trap. It is evaporated and the residue recrystallized from acetonitrile, to yield the 5-(m-fluorobenzylideneamino)-pyridine-2-carboxylic acid methyl ester, melting at 111°-114°.

Workup

  1. customThe starting material is prepared
  2. temperatureis refluxed for 22 hours on a water trap
  3. customIt is evaporated
  4. customthe residue recrystallized from acetonitrile

Sources & evidence

ORD record
ord-f10c7f253ce44564a3d9f9d89673a192
Source dataset
uspto-grants-1981_06
Patent number
US04273779

Reaction notes

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