反应详情

温度

90 °C

Sodium hydroxide (1 g) was dissolved in 30 ml of water, and 1.5 g of the 4-hydroxy-5-hydroxyimino-5,6,7,8-tetrahydroquinoline-3-carboxylic acid ethyl ester obtained in Example 3 was added thereto. The resulting reaction mixture was stirred on an oil bath at 90° C. for 2 hours. After being cooled, the reaction mixture was adjusted to pH 2.2 with dilute hydrochloric acid. The crystals so precipitated were separated by filtration to obtain a yield of 1.2 g of the desired compound. This compound melted (and decomposed) at 285°-286° C. (uncorrected values). Its infrared absorption spectrum (KBr tablet) had absorption peaks at 3440, 3180, 2880, 1650, 1520, 1400, 1230, 970, and 820 cm-1.

1. customThe resulting reaction mixture
2. temperatureAfter being cooled
3. customThe crystals so precipitated
4. customwere separated by filtration