Hydrochloric Acid → HCID 70565662, compound

Participants

Reaction Steps

To a solution of 0.94 g of Boc-L-tyrosyl-D-methionyl-glycyl-L-phenyalanyl-3-amino-1-adamantanecarboxylic acid in 20 ml of dioxane is added 10 ml of a 5.7 N solution of hydrogen chloride in dioxane. The reaction mixture is allowed to stand for 30 minutes at room temperature. The solvent is removed under vacuum and the residue is dissolved in water. The cloudy solution is stirred with a small amount of SupercelHyflo for 30 minutes then filtered and lyophilized to give a white powder. The powder is dried for 2 hours at 50° C. and 0.1 mm pressure to give L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylic acid hydrochloride which is represented by the following formula ##STR27##

Provenance & Evidence