Hydrochloric Acid → HCID 70565662, compound

HRID 1680577Notes

Reaction equation

HRID 1680577 reaction equation
C([NH:8][C@H:9]([C:18]([NH:20][C@@H:21]([C:26]([NH:28][CH2:29][C:30]([NH:32][C@H:33]([C:41]([CH:43]1[C:50]2([NH2:52])[CH2:51][CH:46]3[CH2:47][CH:48]([CH2:53][C:44]1([C:54]([OH:56])=[O:55])[CH2:45]3)[CH2:49]2)=[O:42])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:31])=[O:27])[CH2:22][CH2:23][S:24][CH3:25])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)(OC(C)(C)C)=O.[ClH:57]>O1CCOCC1>[ClH:57].[NH2:8][C@H:9]([C:18]([NH:20][C@@H:21]([C:26]([NH:28][CH2:29][C:30]([NH:32][C@H:33]([C:41]([CH:43]1[C:50]2([NH2:52])[CH2:51][CH:46]3[CH2:47][CH:48]([CH2:53][C:44]1([C:54]([OH:56])=[O:55])[CH2:45]3)[CH2:49]2)=[O:42])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:31])=[O:27])[CH2:22][CH2:23][S:24][CH3:25])=[O:19])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22816341HCID 22816341, compound

Product 1

HCID 70565662HCID 70565662, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 0.94 g of Boc-L-tyrosyl-D-methionyl-glycyl-L-phenyalanyl-3-amino-1-adamantanecarboxylic acid in 20 ml of dioxane is added 10 ml of a 5.7 N solution of hydrogen chloride in dioxane. The reaction mixture is allowed to stand for 30 minutes at room temperature. The solvent is removed under vacuum and the residue is dissolved in water. The cloudy solution is stirred with a small amount of SupercelHyflo for 30 minutes then filtered and lyophilized to give a white powder. The powder is dried for 2 hours at 50° C. and 0.1 mm pressure to give L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxylic acid hydrochloride which is represented by the following formula ##STR27##

Workup

  1. customThe solvent is removed under vacuum
  2. dissolutionthe residue is dissolved in water
  3. filtrationthen filtered
  4. customto give a white powder
  5. customThe powder is dried for 2 hours at 50° C.

Sources & evidence

ORD record
ord-212394497d0249d9a15ede6227a06523
Source dataset
uspto-grants-1981_06
Patent number
US04273704

Reaction notes

Loading…