Hydrochloric Acid → HCID 178433315, compound

HRID 1680846Notes

Reaction equation

HRID 1680846 reaction equation
C([NH:3][C:4]([NH:16][CH2:17][CH2:18][NH2:19])=[N:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[NH:14][CH:13]=[N:12][C:11]=1[CH3:15])#N.[ClH:20]>>[ClH:20].[ClH:20].[ClH:20].[NH2:19][CH2:18][CH2:17][NH:16][C:4]([NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[NH:14][CH:13]=[N:12][C:11]=1[CH3:15])=[NH:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178433308HCID 178433308, compound

Product 1

HCID 178433315HCID 178433315, compound

Procedure

N-Cyano-N'-(2-aminoethyl)-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine (1.0 g) (see Example 10) and 1 N hydrochloric acid (20 ml) were refluxed together for 6 hours. Evaporation and recrystallisation from methanol/isopropanol gave the title compound (0.6 g.), m.p. 195°-196° C. (Found: C, 33.1; H, 6.3; N, 22.8; S, 8.8; Cl, 28.8%. C10H20N6S.3HCl requires: C, 32.8; H, 6.3; N, 23.0; S, 8.8; Cl, 29.1%).

Workup

  1. customEvaporation and recrystallisation from methanol/isopropanol

Sources & evidence

ORD record
ord-8e8c8a39e67246e0a8e646fbf1b5414a
Source dataset
uspto-grants-1981_06
Patent number
US04276301

Reaction notes

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