反应详情

A mixture of 15 g of 1-(3,4-methylenedioxyphenyl)-2-methyl-2-nitropropanol (crude oil), 12 g of thionyl chloride and 80 ml of anhydrous benzene is refluxed for 3 hours. After the reaction, the reaction mixture is evaporated to remove solvent and thionyl chloride. The residue is purified by silica gel chromatography (Solvent: benzene). 9.0 g of 1-(3,4-methylenedioxyphenyl)-1-chloro-2-methyl-2-nitropropane are thereby obtained as an oil.

1. temperatureis refluxed for 3 hours
2. customAfter the reaction
3. customthe reaction mixture is evaporated
4. customto remove solvent and thionyl chloride
5. customThe residue is purified by silica gel chromatography (Solvent: benzene)