HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-(1-Chloro-2-methyl-2-nitropropyl)-2H-1,3-benzodioxole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1,1-Dimethyl-2-hydroxy-2-(3,4-methylenedioxyphenyl)nitroethane | HCID 23454852 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-(1-Chloro-2-methyl-2-nitropropyl)-2H-1,3-benzodioxole | HCID 23454839 | 55.7% |
Reaction Steps
A mixture of 15 g of 1-(3,4-methylenedioxyphenyl)-2-methyl-2-nitropropanol (crude oil), 12 g of thionyl chloride and 80 ml of anhydrous benzene is refluxed for 3 hours. After the reaction, the reaction mixture is evaporated to remove solvent and thionyl chloride. The residue is purified by silica gel chromatography (Solvent: benzene). 9.0 g of 1-(3,4-methylenedioxyphenyl)-1-chloro-2-methyl-2-nitropropane are thereby obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04276304 |
| Source dataset | uspto-grants-1981_06 |
| ORD ID | ord-e5ff0d8ae3ee40c786d3b97c961d1e14 |
| Source note | uspto-grants-1981_06 |