2-(4-Methoxyphenyl)-1,1-dimethylethylamine → alpha-(alpha,alpha-Dimethyl-4-methoxyphenethylimino)-2-benzyloxyacetophenone

HRID 1680879Notes

Reaction equation

HRID 1680879 reaction equation
[OH2:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([CH:18]=O)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:20][C:21]([NH2:32])([CH3:31])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1>CS(C)=O>[CH3:31][C:21]([N:32]=[C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[C:15]([C:14]1[CH:13]=[CH:12][CH:11]=[CH:16][CH:18]=1)=[O:1])([CH3:20])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 918922-(4-Methoxyphenyl)-1,1-dimethylethylamineHCID 204340852-Benzyloxyphenylglyoxal hydrate

Product 1

HCID 23454850alpha-(alpha,alpha-Dimethyl-4-methoxyphenethylimino)-2-benzyloxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent3×

Conditions

Temperature
23 °C

Procedure

1.16 g of 2-benzyloxyphenylglyoxal hydrate are dissolved in one ml of dimethylsulfoxide, and a solution of 0.78 g of α,α-dimethyl-4-methoxyphenethylamine in 1.5 ml of dimethylsulfoxide is added thereto. The mixture is stirred at 23° C. for one hour, whereby a solution of α-(α,α-dimethyl-4-methoxyphenethylimino)-2-benzyloxyacetophenone in dimethylsulfoxide is obtained.

Sources & evidence

ORD record
ord-b559079964734a0f83266a3bc1741736
Source dataset
uspto-grants-1981_06
Patent number
US04276304

Reaction notes

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