1-(3,4-Dimethoxyphenyl)-2-methylpropan-2-amine → alpha-(alpha,alpha-Dimethyl-3,4-dimethoxyphenethylimino)-2-benzyloxyacetophenone

HRID 1680882Notes

Reaction equation

HRID 1680882 reaction equation
[OH2:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([CH:18]=O)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:20][C:21]([NH2:34])([CH3:33])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1>CS(C)=O>[CH3:33][C:21]([N:34]=[C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[C:15]([C:14]1[CH:13]=[CH:12][CH:11]=[CH:16][CH:18]=1)=[O:1])([CH3:20])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=1

Participants

4

Reactant 2

HCID 130206331-(3,4-Dimethoxyphenyl)-2-methylpropan-2-amineHCID 204340852-Benzyloxyphenylglyoxal hydrate

Product 1

HCID 23454857alpha-(alpha,alpha-Dimethyl-3,4-dimethoxyphenethylimino)-2-benzyloxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
20 °C

Procedure

570 mg of 2-benzyloxyphenylglyoxal hydrate are dissolved in 0.5 ml of dimethylsulfoxide, and a solution of 450 mg of α,α-dimethyl-3,4-dimethoxyphenethylamine in 0.7 ml of dimethylsufoxide is added thereto. The mixture is stirred at 20° C. for 2 hours, whereby a solution of α-(α,α-dimethyl-3,4-dimethoxyphenethylimino)-2-benzyloxyacetophenone in dimethylsufoxide is obtained.

Sources & evidence

ORD record
ord-4c99a4a36c974b8294afe7535561f1b3
Source dataset
uspto-grants-1981_06
Patent number
US04276304

Reaction notes

Loading…