1-(2H-1,3-Benzodioxol-5-yl)-2-methylpropan-2-amine → alpha-(alpha,alpha-Dimethyl-3,4-methylenedioxyphenethylimino)-2-benzyloxyacetophenone

HRID 1680888Notes

Reaction equation

HRID 1680888 reaction equation
[OH2:1].[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([CH:18]=O)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:20][C:21]([NH2:33])([CH3:32])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1>CS(C)=O>[CH3:32][C:21]([N:33]=[C:10]([O:9][CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1)[C:15]([C:14]1[CH:13]=[CH:12][CH:11]=[CH:16][CH:18]=1)=[O:1])([CH3:20])[CH2:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1

Participants

4

Reactant 2

HCID 130205981-(2H-1,3-Benzodioxol-5-yl)-2-methylpropan-2-amineHCID 204340852-Benzyloxyphenylglyoxal hydrate

Product 1

HCID 86737825alpha-(alpha,alpha-Dimethyl-3,4-methylenedioxyphenethylimino)-2-benzyloxyacetophenone

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
23 °C

Procedure

1.31 g of 2-benzyloxyphenylglyoxal hydrate are dissolved in 3.5 ml of dimethylsulfoxide, and 0.97 g of α,α-dimethyl-3,4-methylenedioxyphenethylamine are added thereto. The mixture is stirred at 23° C. for 45 minutes, whereby a solution of α-(α,α-dimethyl-3,4-methylenedioxyphenethylimino)-2-benzyloxyacetophenone in dimethylsulfoxide is obtained.

Sources & evidence

ORD record
ord-eb3c6462d2e84cf6ab70b8af83754cd8
Source dataset
uspto-grants-1981_06
Patent number
US04276304

Reaction notes

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