Propylparaben → 4-Hydroxybenzoic Acid

HRID 1680920Notes

Reaction equation

HRID 1680920 reaction equation
[OH:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([O:8]CCC)=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+]>O>[OH:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7175PropylparabenHCID 14798Sodium Hydroxide3×

Product 1

HCID 1354-Hydroxybenzoic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

891 g of n-propyl 4-hydroxybenzoate were neutralised in 712 ml of water with 260 ml of 50% strength sodium hydroxide solution in two stages. After the first stage of the neutralisation (247 ml of sodium hydroxide solution), the resulting clear solution was kept at 20° C. for 96 hours. When the neutralisation had been completed (13 ml of sodium hydroxide solution), spray-drying resulted in a product with a 4-hydroxybenzoic acid content of 0.1 percent by weight and a water content of 0.3% by weight.

Workup

  1. customspray-drying

Sources & evidence

ORD record
ord-84e1797d9bb34e2a88020c5a9f6ac2d4
Source dataset
uspto-grants-1981_06
Patent number
US04276431

Reaction notes

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