Propylparaben → 4-Hydroxybenzoic Acid

Participants

Reaction Steps

891 g of n-propyl 4-hydroxybenzoate were neutralised in 712 ml of water with 260 ml of 50% strength sodium hydroxide solution in two stages. After the first stage of the neutralisation (247 ml of sodium hydroxide solution), the resulting clear solution was kept at 20° C. for 96 hours. When the neutralisation had been completed (13 ml of sodium hydroxide solution), spray-drying resulted in a product with a 4-hydroxybenzoic acid content of 0.1 percent by weight and a water content of 0.3% by weight.

Provenance & Evidence