Triethyl orthoacetate → HCID 14802298, compound

HRID 1680953Notes

Reaction equation

HRID 1680953 reaction equation
[NH2:1][C:2]1[C:3]([NH:13][CH2:14][CH3:15])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([Cl:12])=[CH:7]2.[C:16](OCC)(OCC)(OCC)[CH3:17]>>[CH3:15][C:14]1[N:13]([CH2:16][CH3:17])[C:3]2[CH:4]=[CH:5][C:6]3[CH:7]=[C:8]([Cl:12])[CH:9]=[N:10][C:11]=3[C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 66221Triethyl orthoacetateHCID 15023099HCID 15023099, compound

Product 1

HCID 14802298HCID 14802298, compound

Procedure

14 g (64 mmol) of 8-amino-3-chloro-7-ethylaminoquinoline and 42 g (0.26 mol) of triethyl orthoacetate are stirred at 100° C. for 1 hour. The mixture is allowed to cool to room temperature, excess orthoester is evaporated off, and the residue is recrystallized from ethyl acetate.

Workup

  1. customexcess orthoester is evaporated off
  2. customthe residue is recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-760d525b50e44d8493931c58cb8d965b
Source dataset
uspto-grants-1992_12
Patent number
US05167695

Reaction notes

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